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KMID : 0613820140240070791
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Journal of Life Science
2014 Volume.24 No. 7 p.791 ~ p.797
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Comparison of Mitochondria-related Conserved Genes in Eukaryotes and Prokaryotes
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Lee Dong-Geun
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Abstract
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Sixty-two conserved orthologous groups (OGs) of proteins, in 63 prokaryotes and seven eukaryotes were analyzed to identify essential proteins in the mitochondria of eukaryotes, and their counterparts in prokaryotes. Twenty OGs were common in eukaryotic mitochondria, and all were translation related. Encephalitozoon cuniculi, an obligate parasitic eukaryote, shares no common mitochondrial OGs with the other 69 organisms. Seventeen conserved OGs were mitochondria related in the 69 organisms. Mitochondria related- and nonrelated-OGs were divided into prokaryotic genomes (p<0.001, paired t-test) unlike eukaryotic genomes in the distance value analysis. The most commonly conserved mitochondria-related OG was COG0048-KOG1750 (ribosomal small subunit S12), whereas it was COG0100-KOG0407 (ribosomal small subunit S11) in nonrelated OGs. These results could be applied in scientific research to determine phylogenetic relationships and in areas such as drug development.
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KEYWORD
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Clusters of Orthologous Groups of proteins (COG), conserved gene, euKaryotic Orthologous Group (KOG), mitochondria
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